Of the 1,035 patients treated with EPCLUSA for 12 weeks in the ASTRAL 1, ASTRAL 2 and ASTRAL 3 studies, 1,015 (98 per cent) achieved SVR12. In ASTRAL 4, patients with decompensated cirrhosis receiving EPCLUSA with RBV for 12 weeks achieved a high SVR12 rate (94 per cent) compared to those who received EPCLUSA for 12 weeks or 24 weeks without RBV (83 per cent and 86 per cent, respectively). The most common adverse events in the four ASTRAL studies were headache, fatigue and nausea, and were comparable in incidence to the placebo group included in ASTRAL 1..
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